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Article

Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart.

Cardiovascular diabetology - 12 May 2018

Cerychova Radka, Bohuslavova Romana, Papousek Frantisek, Sedmera David, Abaffy Pavel, Benes Vladimir, Kolar Frantisek, Pavlinkova Gabriela

Abstract excerpt

BACKGROUND: Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition remain poorly understood. We examined whether hypoxia-inducible factor 1 alpha, in combination with exposure to a diabetic intrauterine environment, influences the function and molecular structure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29753320
DOI: 10.1186/s12933-018-0713-0
PMCID: PMC5948854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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