Back to search

Article

IL-7-mediated expansion of autologous lymphocytes increases CD8 <sup>+</sup> VLA-4 expression and accumulation in glioblastoma models

2024-04-01

Abstract excerpt

The efficacy of T cell-activating therapies against glioma is limited by an immunosuppressive tumor microenvironment and tumor-induced T cell sequestration. We investigated whether peripherally infused non-antigen specific autologous lymphocytes (ALT) could accumulate in intracranial tumors. We observed that non-specific autologous CD8 + ALT cells can indeed accumulate in this context, despite endogenous T cell s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e145581c-7c9b-51b7-8588-8c64a755acfe
DOI
10.1101/2024.04.01.587634
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
IL-7-mediated expansion of autologous lymphocytes increases CD8 <sup>+</sup> VLA-4 expression and accumulation in glioblastoma modelsDOI 10.1101/2024.04.01.587634
IL-7–mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma modelsSemantic proximity
7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomasSemantic proximity
Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcomeSemantic proximity
Inflammatory endothelial cells promote infiltration of antigen-licensed cytotoxic T cells in malignant gliomas after irradiationSemantic proximity
B7-homolog 1 expression by human glioma: a new mechanism of immune evasionSemantic proximity
Chimeric antigen receptor T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastomaSemantic proximity
CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokinesSemantic proximity
Brain Microenvironment Promotes the Final Functional Maturation of Tumor-Specific Effector CD8+ T CellsSemantic proximity
Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapySemantic proximity
Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccinationSemantic proximity
Polyclonal expansion of functional tumor-reactive lymphocyte infiltrating glioblastoma for personalized cell therapySemantic proximity
Expansion of endogenous T cells in CSF of pediatric CNS tumor patients undergoing locoregional delivery of IL13R⍺2-targeting CAR T cells: an interim analysisSemantic proximity
Select a neighboring publication to make it the new centre.