Article

Inhibition of Acyl-CoA Synthetase Long Chain Isozymes Decreases Multiple Myeloma Cell Proliferation and Causes Mitochondrial Dysfunction

2024-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5-year survival rate of 59%. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression; however, the underlying mechanisms remain unclear. Acyl-CoA synthetase long-chain family members (ACSLs) convert free long-chain fatty acids into fatty acyl-CoA esters and play key roles in catabolic and an...

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Literature Corpus work: f1207017-9c00-54a9-9ed4-e3951ffb52f8
DOI: 10.1101/2024.03.13.583708

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