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Article

Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.

Frontiers in immunology - 1 Jan 2020

Cooke Rachel Elizabeth, Quinn Kylie Margaret, Quach Hang, Harrison Simon, Prince Henry Miles, Koldej Rachel, Ritchie David

Abstract excerpt

New diagnoses of multiple myeloma (MM) tend to occur after the age of 60, by which time thymic output is severely reduced. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies relies on homeostatic proliferation of peripheral T cells rather than replenishment by new thymic emigrants. To assess lymphocyte recovery and phenotype in patients with newly diagnosed MM (NDMM) and...

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Identifiers

PMID: 33013907
DOI: 10.3389/fimmu.2020.02153
PMCID: PMC7494758

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