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CD8 + T cell metabolism and function are suppressed by long-chain fatty acid uptake from the bone marrow microenvironment in Multiple Myeloma

2023-01-24

Abstract excerpt

<h4>Background: </h4> Multiple Myeloma (MM) is a plasma cell malignancy that develops in the bone marrow. Function of T lymphocytes is impaired in patients with MM and the bone marrow microenvironment is described as hostile for T cell activity. Precise suppressive mechanisms within the bone marrow microenvironment remain poorly defined but will impact efficacy of bispecific T cell engager and chimeric antigen rec...

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Literature Corpus work
c2c9cc79-89d8-53da-8555-112cb732fbb0
DOI
10.21203/rs.3.rs-2500541/v1
Open publication

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CD8 + T cell metabolism and function are suppressed by long-chain fatty acid uptake from the bone marrow microenvironment in Multiple MyelomaDOI 10.21203/rs.3.rs-2500541/v1
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