Article

<i>Pogz</i> deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology

2018-10-07

Abstract excerpt

Genes implicated in autism spectrum disorder (ASD) are enriched with chromatin regulators, but the mechanisms leading to the abnormal behavior and cognition are still unclear. Animal models are crucial for studying the effects of mutations on brain function and behavior. We generated conditional knockout mice with brain-specific mutation in Pogz , a heterochromatin regulator recurrently mutated in ASD and other n...

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Literature Corpus work: e12d26e2-d250-59ca-acc2-ebf4a85c7d20
DOI: 10.1101/437442

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