Article

Analyses of Conditional Knockout Mice for Pogz, a Responsible Gene for Neurodevelopmental Disorders, in Excitatory and Inhibitory Neurons in the Brain

2024-02-13

Abstract excerpt

POGZ (Pogo transposable element derived with ZNF domain) is known to function as a regulator of gene expression. While variations in the POGZ gene have been associated with intellectual disabilities and developmental delays in humans, the exact pathophysiological mechanisms re-main unclear. To shed light on this, we created two lines of conditional knockout mice for Pogz, one specific to excitatory neurons (Emx1-P...

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Literature Corpus work: e821b93a-c931-554b-b051-6707909eaeb3
DOI: 10.20944/preprints202402.0715.v1

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