Article

Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environment

2022-10-20

Abstract excerpt

Multiple cell types, molecules, and processes contribute to inhibition of anti-tumor effector responses, often frustrating effective immunotherapy. Among these, Foxp3+ CD4+ cells (Tregs) are well-recognized to play an immunosuppressive role in the tumor microenvironment. The first clinically successful checkpoint inhibitor, anti-CTLA-4 antibody, may deplete Tregs at least in part by antibody-dependent cellular cyt...

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Literature Corpus work: e0fcf9b7-6ffc-5c44-93b3-7d603d8c0ee4
DOI: 10.1101/2022.10.17.512537

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