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CD40 Agonism in Pancreatic Ductal Adenocarcinoma: Expression, Biology, and Therapeutic Targeting

2026-05-05

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal and is largely refractory to immune checkpoint inhibition, reflecting limited antigen-specific priming, dominant myeloid suppression, dense desmoplasia, and abnormal vasculature that together enforce immune exclusion. CD40 is a central costimulatory receptor that links CD4⁺ T cell help (via CD40L/CD154) to antigen-presenting cell (APC) licensing and eff...

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Literature Corpus work
01255763-dc32-5ca6-b7a4-b842f3abdadd
DOI
10.20944/preprints202605.0143.v1
Open publication

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