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Article

Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome

30 Aug 2019

Abstract excerpt

Background and Aims Alagille syndrome (ALGS) is a multisystem developmental disorder characterized by bile duct (BD) paucity, caused primarily by haploinsufficiency of the Notch ligand jagged1. The course of the liver disease is highly variable in ALGS. However, the genetic basis for ALGS phenotypic variability is unknown. Previous studies have reported decreased expression of the transcription factor SOX9 (sex...

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Share to Gallbladder and Bile Duct Disorders
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Share to Pediatric Hepatobiliary Diseases and Treatments

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PMID: 31469182
DOI: 10.1002/hep.30912

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