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Article

Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

27 Sept 2017

Abstract excerpt

Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1 mutations. Here, we report that zebrafish embryos with compound homozygous mutations in two Notch ligand genes, jagged1b (jag1b) and jagged2b (jag2b) exhibit a complete loss of canonical Notch activity and duct cells within the liver and exocrine pancreas, whereas hepatocyte and acinar pancreas...

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PMID: 28974684
DOI: 10.1038/s41467-017-00666-6

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