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Article

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.

Development (Cambridge, England) - 1 Dec 2010

Hofmann Jennifer J, Zovein Ann C, Koh Huilin, Radtke Freddy, Weinmaster Gerry, Iruela-Arispe M Luisa

Abstract excerpt

Mutations in the human Notch ligand jagged 1 (JAG1) result in a multi-system disorder called Alagille syndrome (AGS). AGS is chiefly characterized by a paucity of intrahepatic bile ducts (IHBD), but also includes cardiac, ocular, skeletal, craniofacial and renal defects. The disease penetration and severity of the affected organs can vary significantly and the molecular basis for this broad spectrum of pathology...

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Topics

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Share to Alagille Syndrome
Share to Bile Ducts, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Chemical Analysis

Share to Cell Aggregation

Share to Jagged-1 Protein

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Share to Serrate-Jagged Proteins

Share to SOX9 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 21062863
DOI: 10.1242/dev.052118
PMCID: PMC2976287

Genes

JAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.PMID 21062863Read ↗

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