Article

The Juvenile Idiopathic Arthritis (JIA) Susceptibility Locus, IL2RA, Includes An Intronic Enhancer That Is Attenuated By JIA-Associated Genetic Variants

2019-02-18

Abstract excerpt

Like most rheumatic diseases, genetic risk loci for juvenile idiopathic arthritis (JIA) are highly enriched for H3K4me1/H3K27ac histone marks, epigenetic signatures often associated with enhancer function. We sought to determine whether an H3K4me1/H3K27ac region of the JIA risk locus, IL2RA exhibits enhancer function and whether enhancer function is altered by JIA-associated genetic variants. We used a conventiona...

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Literature Corpus work: e0ec6014-9ee0-534a-a861-0de4fc16d3e5
DOI: 10.1101/554006

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