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Article

DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress

6 Jan 2012

Abstract excerpt

Mammalian male germ cells should be maintained below body temperature for proper development. Here, we investigated how male germ cells respond to heat stress. A short exposure of mouse testes to core body temperature induced phosphorylation of eIF2α and the formation of stress granules (SGs) in male germ cells. We observed that DAZL, a germ cell-specific translational regulator, was translocated to SGs upon heat...

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PMID: 22223682
DOI: 10.1242/dev.075846

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