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Article

Functional validation of driver mutation-specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity.

The Journal of pathology - 1 Oct 2026

van den Bosch Qcc, Verdijk R M, Fadlelseed H, van den Bosch Tpp, Owens S, Kennedy S, Kilic E, Brosens E

Abstract excerpt

Uveal melanoma (UM) is a deadly ocular malignancy with well-described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high-risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers associated with high-risk UM, with protein expression level validation...

Read the complete abstract on PubMed

Topics

Humans
Uveal Neoplasms
Melanoma
Uveal Melanoma
Animals
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Zebrafish

Mutation

Cell Plasticity

Cell Line, Tumor

Cell Movement

Tumor Suppressor Proteins

Cell Proliferation

Ubiquitin Thiolesterase

Gene Expression Regulation, Neoplastic

RNA Splicing Factors

Eukaryotic Initiation Factor-1

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 42482451
DOI: 10.1002/path.70094
PMCID: PMC13576891

Genes

COL9A3
CD44
ABCB5
PAX3
RBFOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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