Article

Induction of tumor-initiating cells and glioma-initiating cells from fetal neural stem cells through p53 genome editing

2022-02-24

Abstract excerpt

The elucidation of the properties of malignant glioma and development of therapeutic methods require model cells with characteristics such as invasiveness, multinuclearity, and ability for mitosis. A previous study has shown that overexpression of active HRas (HRasL61) in neural stem/progenitor cells isolated from fetal telencephalic neuroepithelial cells with homozygous deletion of the p53 locus forms glioma-init...

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Literature Corpus work: e05d7b2f-6490-5497-aaca-4ef8abc870bd
DOI: 10.1101/2022.02.24.481795

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