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Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

22 Feb 2016

Abstract excerpt

Glioma tumour-initiating cells (GTICs) can originate upon the transformation of neural progenitor cells (NPCs). Studies on GTICs have focused on primary tumours from which GTICs could be isolated and the use of human embryonic material. Recently, the somatic genomic landscape of human gliomas has been reported. RTK (receptor tyrosine kinase) and p53 signalling were found dysregulated in ∼90% and 86% of all...

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PMID: 26899176
DOI: 10.1038/ncomms10743

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