Article

Protection against <i>Clostridioides difficile</i> disease by a naturally avirulent <i>C. difficile</i> strain

2024-05-07

Abstract excerpt

Clostridioides difficile (C. difficile) strains belonging to the epidemic BI/NAP1/027 (RT027) group have been associated with increased transmissibility and disease severity. In addition to the major toxin A and toxin B virulence factors, RT027 strains also encode the CDT binary toxin. Our lab previously identified a toxigenic RT027 isolate, ST1-75, that is avirulent in mice despite densely colonizing the colon. H...

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Literature Corpus work: e03ed1e9-c735-5073-8d30-021583faf173
DOI: 10.1101/2024.05.06.592814

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