Article

A phosphorylation switch in PAGE4 drives MED12-mutant fibroid pathogenesis

2026-04-02

Abstract excerpt

Recurrent somatic mutations in MED12, found in ∼70% of uterine leiomyomas (ULs), define the dominant molecular subtype of these highly prevalent tumors, yet the downstream effector mechanisms remain poorly understood. Using an integrated multi-omics workflow, encompassing discovery-phase DDA proteomics of matched leiomyoma–myometrium pairs, validation-phase DIA proteomics across genetically stratified cohorts (MED...

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Literature Corpus work: 351f2a6b-f452-5a33-b02c-e5f974291a1d
DOI: 10.64898/2026.03.31.715552

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