Article

Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema

2023-01-07

Abstract excerpt

<h4>ABSTRACT</h4> Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression in lymphedematous arm compared to normal arm in patients. The role of APLN in LD was confirmed in APLN-knock...

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Literature Corpus work: dff79e22-86c4-549c-aa08-4f8346203336
DOI: 10.1101/2023.01.05.522869

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