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Article

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

The Journal of investigative dermatology - 1 Jul 2013

Nikitenko Leonid L, Shimosawa Tatsuo, Henderson Stephen, Mäkinen Taija, Shimosawa Hiromi, Qureshi Uzma, Pedley R Barbara, Rees Margaret C P, Fujita Toshiro, Boshoff Chris

Abstract excerpt

Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the Adm gene (adrenomedullin gene). AM and its putative receptor calcitonin receptor-like receptor (CLR) are implicated in angiogenesis and lymphangiogenesis during embryogenesis and wound...

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Identifiers

PMID: 23364478
DOI: 10.1038/jid.2013.47
PMCID: PMC3682392

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