Article

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population

2025-02-19

Abstract excerpt

Chronic lymphedema is a progressive, disfiguring disease that results from dysfunction of the lymphatic vasculature, causing distal accumulation of interstitial fluid, localized development of tissue edema, and expansion of subcutaneous adipose tissue (SAT). As the molecular mechanisms governing SAT remodeling in this disease are unclear, we performed single-nucleus RNA sequencing on paired control and affected SA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e31354f2-699e-511e-9024-039e61178ee7
DOI: 10.1101/2025.02.18.638907

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell populationDOI 10.1101/2025.02.18.638907Read

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedemaSemantic proximity Read

Identification of novel hub genes and pathways predictive of fibrosis progression in cancer-related lymphedema through integrated multi-omicsSemantic proximity Read

Multi-level analysis of adipose tissue reveals the relevance of perivascular subpopulations and an increased endothelial permeability in early-stage lipedemaSemantic proximity Read

Single-nuclei Transcriptome of Human AT Reveals Metabolically Distinct Depot-Specific Adipose Progenitor SubpopulationsSemantic proximity Read

Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and FibrosisSemantic proximity Read

Multi-omics characterization of lymphedema-induced adipose tissue from breast cancer patientsSemantic proximity Read

Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial TranscriptomicsSemantic proximity Read

Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic AlopeciaSemantic proximity Read

The shifting of dominating roles between structural cells and immune cells are key regulators of human adipose tissues agingSemantic proximity Read

Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and PainSemantic proximity Read

Single-cell RNA sequencing reveals cellular and molecular landscape of fetal cystic hygromaSemantic proximity Read

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic SignalingSemantic proximity Read