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Article

ALDH2 Polymorphism rs671 is A Predictor of Immune Checkpoint Inhibitor Efficacy Against Chest Malignancies

2021-03-03

Abstract excerpt

<h4>Background: </h4> Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the endogenous aldehyde detoxification of various types of cells. ALDH2*2 , a variant allele of the ALDH2 polymorphism rs671, leads to decreased enzymatic activity. ALDH2*2 may enhance tumor antigen presentation due to aldehyde-induced DNA damage while suppressing peripheral blood T cell counts and T cell activation. Methods On the...

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Literature Corpus work
dff60f17-9652-58f4-abf8-ce89a66a0c0a
DOI
10.21203/rs.3.rs-257337/v1
Open publication

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ALDH2 Polymorphism rs671 is A Predictor of Immune Checkpoint Inhibitor Efficacy Against Chest MalignanciesDOI 10.21203/rs.3.rs-257337/v1
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