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Article

Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites.

Cancer biology & therapy - 1 Jan 2015

El-Deiry Wafik S, Vijayvergia Namrata, Xiu Joanne, Scicchitano Angelique, Lim Bora, Yee Nelson S, Harvey Harold A, Gatalica Zoran, Reddy Sandeep

Abstract excerpt

Metastatic colorectal cancer (mCRC) carries a poor prognosis with an overall 5-year survival of 13.1%. Therapies guided by tumor profiling have suggested benefit in advanced cancer. We used a multiplatform molecular profiling (MP) approach to identify key molecular changes that may provide therapeutic options not typically considered in mCRC. We evaluated 6892 mCRC referred to Caris Life Sciences by MP including...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26553611
DOI: 10.1080/15384047.2015.1113356
PMCID: PMC4847814

Genes

BRAF
KRAS
MET
MGMT
RRM1
EGFR
TUBB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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