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Article

Genomic landscape and clinical characteristics of ERBB2/HER2-mutated colorectal cancers.

The oncologist - 6 Aug 2026

Aksu Muhammed Dogukan, Peniche Paola Zinser, Baytar Doga Kahramangil, Jambunathan Bhaghyasree, Jan Yu Jen Alexander, Hsieh Ronan, Rahman Shafia, Krauss John C, Veenstra Christine M, Sahin Ibrahim Halil

Abstract excerpt

BACKGROUND: Molecular underpinnings and clinical characteristics of ERBB2/HER2-mutated colorectal cancers (CRCs) remain poorly understood. We aimed to comprehensively characterize the genomic landscape and clinical features of ERBB2/HER2-mutated CRC and to compare them with those of ERBB2/HER2-amplified CRC. PATIENTS AND METHODS: We analyzed cBioPortal data from 4348 CRC patients with available ERBB2/HER2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42536421
DOI: 10.1093/oncolo/oyag302
PMCID: PMC13466721

Genes

ERBB2
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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