Article

Spatial Profiling Reveals Equivalence-Derived Molecular Signatures of Brain Mimicry and Adaptation in Breast Cancer Brain Metastases

2025-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Brain metastases (BrMets), common for advanced-stage breast cancer patients, are associated with poor median survival and accompanied by severe neurologic decline. Halting the progression of breast cancer brain metastases (BCBMs) may require modulation of the tumor microenvironment (TME), yet little is known about the impact of the primary breast TME on brain tropism, or how, once there, metasta...

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Literature Corpus work: dfc62013-e1c2-5d08-b589-6057c41e7c74
DOI: 10.1101/2025.01.13.631781

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