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Article

PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer.

International journal of biological sciences - 1 Jan 2023

Ji Qian, Li Hengchao, Cai Zhiwei, Yuan Xiao, Pu Xi, Huang Yumeng, Fu Shengqiao, Chu Liangmei, Jiang Chongyi, Xue Junli, Zhang Xiaoxin, Li Rongkun

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is closely associated with tumor invasion and metastasis. However, key regulators of EMT in pancreatic ductal adenocarcinoma (PDAC) need to be further studied. Bioinformatics analyses of pancreatic cancer public datasets showed that glycogen phosphorylase L (PYGL) expression is elevated in quasimesenchymal PDAC (QM-PDAC) and positively associated with EMT. In vitro cellular...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 37063425
DOI: 10.7150/ijbs.76756
PMCID: PMC10092766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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