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Article

Hydrogen sulfide represses androgen receptor transactivation by targeting at the second zinc finger module.

The Journal of biological chemistry - 25 Jul 2014

Zhao Kexin, Li Shuangshuang, Wu Lingyun, Lai Christopher, Yang Guangdong

Abstract excerpt

Androgen receptor (AR) signaling is indispensable for the development of prostate cancer from the initial androgen-dependent state to a later aggressive androgen-resistant state. This study examined the role of hydrogen sulfide (H(2)S), a novel gasotransmitter, in the regulation of AR signaling as well as its mediation in androgen-independent cell growth in prostate cancer cells. Here we found that H(2)S inhibits...

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Identifiers

PMID: 24942741
DOI: 10.1074/jbc.M114.559518
PMCID: PMC4110290

Genes

TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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