Article

FOSL1 drives the malignant progression of pancreatic cancer cells by regulating cell stemness, metastasis and multidrug resistance

2024-10-24

Abstract excerpt

<title>Abstract</title> <p>Background Targeted therapy is a key strategy for the treatment of advanced and metastatic pancreatic cancer, one of the leading causes for cancer-related death worldwide. To address the limitations of existing targeted drugs, there is an urgently need to find novel targets and therapeutic strategies. Transcription factor FOSL1 is a potential therapeutic target for challenging pancreat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df8509f4-4977-5eee-a6c1-41cebf72ffeb
DOI: 10.21203/rs.3.rs-5142768/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FOSL1 drives the malignant progression of pancreatic cancer cells by regulating cell stemness, metastasis and multidrug resistanceDOI 10.21203/rs.3.rs-5142768/v1Read

The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasionSemantic proximity Read

HOXA11-AS1 promotes PD-L1 mediated immune escape and metastasis of hypopharyngeal carcinoma by facilitating the association of PTBP1 with FOSL1Semantic proximity Read

FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targetedSemantic proximity Read

Genome-scale activation screen reveals lncRNA HNF1A-AS1 as a novel therapeutic target for pancreatic cancer metastasisSemantic proximity Read

LncRNA ZFAS1 promotes pancreatic adenocarcinoma metastasis via the RHOA/ROCK2 pathway by sponging miR-3924Semantic proximity Read

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.Semantic proximity Read

Expression of β-catenin, LEF-1, MMP7 and SFRP5 associated with poor outcome in pancreatic cancerSemantic proximity Read

HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem CellsSemantic proximity Read

MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progressionSemantic proximity Read

HMG Box-Containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic ProgressionSemantic proximity Read

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonizationSemantic proximity Read

Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28Semantic proximity Read