Article

Post-ictal neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy

2019-04-10

Abstract excerpt

Mouse models of mesial temporal lobe epilepsy recapitulate aspects of human epilepsy, which is characterized by neuronal network remodeling in the hippocampal dentate gyrus. Observational studies suggest that this remodeling is associated with altered Wnt pathway signaling, although this has not been experimentally examined. We used the well-characterized mouse intrahippocampal kainate model of temporal lobe epile...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df811828-27b9-5051-8216-6d6d2378948e
DOI: 10.1101/604975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Post-ictal neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsyDOI 10.1101/604975Read

Transcriptome profiling implicates a role for Wnt signaling during epileptogenesis in a mouse model of temporal lobe epilepsySemantic proximity Read

High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsySemantic proximity Read

High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsySemantic proximity Read

Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated MicrogliaSemantic proximity Read

EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUSSemantic proximity Read

Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy.Semantic proximity Read

Wnt signaling in the nervous system and in Alzheimer's diseaseSemantic proximity Read

Wnts in adult brain: from synaptic plasticity to cognitive deficienciesSemantic proximity Read

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic miceSemantic proximity Read

Epileptogenesis dynamics driven by peritumoral circuit rewiring in gangliogliomasSemantic proximity Read

Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.Semantic proximity Read

Characterising the role of canonical Wnt signalling in adult hippocampal stem cellsSemantic proximity Read