Article

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice

2018-11-21

Abstract excerpt

Many genes differentially expressed in brain tissue from human alcoholics and animals that have consumed large amounts of alcohol are components of the innate immune toll-like receptor (TLR) pathway. TLRs initiate inflammatory responses via two branches: (1) MyD88-dependent or (2) TRIF-dependent. All TLRs signal through MyD88 except TLR3. Prior work demonstrated a direct role for MyD88-dependent signaling in regul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df62bc21-f199-505b-887e-1ab569610a2c
DOI: 10.1101/476457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male miceDOI 10.1101/476457Read

Effects of innate immune activation by Toll-like receptor agonists on ethanol consumption and preference in FVB/NJ x C57BL/6J hybrid miceSemantic proximity Read

Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumptionSemantic proximity Read

NLRP3: a new therapeutic target in alcoholic liver diseaseSemantic proximity Read

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.Semantic proximity Read

Evidence for Involvement of the Alcohol Consumption WDPCP Gene in Lipid Metabolism, and Liver CirrhosisSemantic proximity Read

Innate Immunity and AlcoholSemantic proximity Read

Evidence for Involvement of <i>WDPCP</i> Gene in Alcohol Consumption, Lipid Metabolism, and Liver CirrhosisSemantic proximity Read

Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J miceSemantic proximity Read

TLR4 signaling and the inhibition of liver hepcidin expression by alcohol.Semantic proximity Read

CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration.Semantic proximity Read

Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-α-Related Depression in Hepatitis C Virus Infection.Semantic proximity Read

Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating LeukocytesSemantic proximity Read