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DNA methylation protects cancer cells against senescence

2024-08-23

Abstract excerpt

Inhibitors of DNA methylation such as 5-aza-deoxycytidine are widely used in experimental and clinical settings. However, their mechanism of action is such that DNA damage inevitably co-occurs with loss of DNA methylation, making it challenging to discern their respective effects. Here we deconvolute the effects of decreased DNA methylation and DNA damage on cancer cells, by using degron alleles of key DNA methyla...

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Identifiers and source

Literature Corpus work
df4fa7ae-bb74-5850-bf29-c7deebcb0006
DOI
10.1101/2024.08.23.609297
Open publication

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DNA methylation protects cancer cells against senescenceDOI 10.1101/2024.08.23.609297
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