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Article

DNA methylation screening identifies driver epigenetic events of cancer cell survival.

Cancer cell - 15 May 2012

De Carvalho Daniel D, Sharma Shikhar, You Jueng Soo, Su Sheng-Fang, Taberlay Phillippa C, Kelly Theresa K, Yang Xiaojing, Liang Gangning, Jones Peter A

Abstract excerpt

Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant transformation. Whether cancer cells are dependent on these abnormal epigenetic modifications remains elusive. We used experimental and bioinformatic approaches to unveil genomic regions that require DNA methylation for survival of cancer cells. First, we surveyed the residual DNA methylation profiles in cancer cells with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22624715
DOI: 10.1016/j.ccr.2012.03.045
PMCID: PMC3395886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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