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Epigenetic Regulation of Cellular Senescence in Gastrointestinal Cancer

25 Mar 2025

Abstract excerpt

Gastrointestinal (GI) cancers, encompassing malignancies of the digestive tract, are significant contributors to global cancer morbidity and mortality. Despite advancements in molecular insights and therapeutic approaches, the prognosis remains dismal because of persistent treatment resistance and metastasis. Cellular senescence, a permanent halt in the cell cycle due to various stressors, plays dual roles in...

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PMID: 40130566
DOI: 10.1158/1535-7163.mct-24-0949

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