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Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticity

11 Feb 2023

Abstract excerpt

Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently we observed the unfolded protein response (UPR) triggers EMP through the inositol-requiring protein 1 (IRE1α)-X-box-binding protein 1 spliced (XBP1s) axis, enhancing glucose shunting to protein N glycosylation. To better understand the genomic targets of XBP1s, we identified...

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PMID: 36772828
DOI: 10.1093/nar/gkad077

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