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Article

Novel bi-allelic DNAH3 variants cause oligoasthenoteratozoospermia.

Frontiers in endocrinology - 1 Jan 2024

Li Shu, Zhang Zexin, Xie Linna, Zhao Yanqiu, Chen Hongtai, Zhang Shijia, Cai Yixiang, Ren Bingjie, Liu Wensheng, Tang Songxi, Sha Yanwei

Abstract excerpt

Background: Oligoasthenoteratozoospermia (OAT) is a widespread cause of male infertility. One of the usual clinical manifestations of OAT is multiple morphological abnormalities of the sperm flagella (MMAF), which are frequently associated with mutations and defects in the dynein family. However, the relationship between the newly identified Dynein Axonemal Heavy Chain 3 (DNAH3) mutation and oligonasthenospermia...

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Identifiers

PMID: 39588341
DOI: 10.3389/fendo.2024.1462509
PMCID: PMC11586517

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