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Article

Novel bi-allelic variants in DNAH10 lead to multiple morphological abnormalities of sperm flagella and male infertility.

Asian journal of andrology - 1 Jul 2025

Shoaib Muhammad, Zubair Muhammad, Shah Wasim, Uddin Meftah, Hussain Ansar, Mustafa Ghulam, Rahim Fazal, Zhang Huan, Ali Imtiaz, Abbas Tanveer, Raza Yousaf, Fan Sui-Xing, Shi Qing-Hua

Abstract excerpt

ABSTRACT: Multiple morphological abnormalities of sperm flagella (MMAF) is a severe form of asthenoteratozoospermia, characterized by morphological abnormalities and reduced motility of sperm, causing male infertility. Although approximately 60% of MMAF cases can be explained genetically, the etiology of the remaining cases is unclear. Here, we identified two novel compound heterozygous variants in the gene,...

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Source

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Identifiers

PMID: 39996363
DOI: 10.4103/aja2024116
PMCID: PMC12279355

Genes

DNAH10

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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