Article

c-di-GMP regulates RNA chaperone activity of PlzA in the Lyme disease spirochete

2023-04-04

Abstract excerpt

PlzA is a c-di-GMP-binding protein crucial for adaptation of the Lyme disease spirochete Borrelia ( Borreliella ) burgdorferi during its enzootic life cycle. Unliganded apo -PlzA is important for vertebrate infection, while liganded holo -PlzA is important for tick acquisition; however, the biological function of PlzA has remained enigmatic. Here we report that PlzA has RNA chaperone activity that is inhibite...

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Literature Corpus work: df106a9a-78de-5c27-894c-abcf4838a530
DOI: 10.22541/au.168060960.03851580/v1

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