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c‐di‐GMP regulates activity of the PlzA RNA chaperone from the Lyme disease spirochete

21 Apr 2023

Abstract excerpt

PlzA is a c-di-GMP-binding protein crucial for adaptation of the Lyme disease spirochete Borrelia (Borreliella) burgdorferi during its enzootic life cycle. Unliganded apo-PlzA is important for vertebrate infection, while liganded holo-PlzA is important for survival in the tick; however, the biological function of PlzA has remained enigmatic. Here, we report that PlzA has RNA chaperone activity that is inhibited...

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PMID: 37086029
DOI: 10.1111/mmi.15066

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