Article

Discovery of Novel c-di-GMP-Related Genes in <em>Leptospira interrogans</em>

2025-05-02

Abstract excerpt

Cyclic di-GMP (bis-(3′ → 5′) cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation. Its intracellular levels are dynamically controlled by diguanylate cyclases (DGCs), which synthesize c-di-GMP from GTP, and phosphodiesterases (PDEs), which degrade it into l...

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Literature Corpus work: 39d53bca-6ce7-5d2e-9337-891a9fbc82e8
DOI: 10.20944/preprints202505.0068.v1

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