An alternative miRISC targeting a coding mutation site in <i>FOXL2</i> links to granulosa cell tumor

Abstract excerpt

<h4>ABSTRACT</h4> Recent evidence suggests that animal microRNAs (miRNAs) can target coding sequences (CDSs); however, the pathophysiological importance of such targeting remains unknown. Here, we show that a somatic heterozygous missense mutation (c.402C>G; p.C134W) in FOXL2 , a feature shared by virtually all adult-type granulosa cell tumors (AGCTs), introduces a target site for miR-1236, which induces haploin...

Topics

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• Allelic Imbalance
• Argonaute Proteins
• Cell Death
• DEAD-box RNA Helicases
• Forkhead Box Protein L2
• Gene Knockout Techniques
• Granulosa Cell Tumor
• Open Reading Frames

Identifiers and source

Literature Corpus work

defe622a-5903-5b8c-af02-5e95bd9f9487

DOI

10.1101/2020.02.18.954487