Article

Structure of the antidiuretic hormone vasopressin receptor signalling complex

2020-12-22

Abstract excerpt

Arginine-vasopressin (AVP) is a neurohypophysial peptide known as the antidiuretic hormone. It forms an active signalling complex with the V2 receptor (V2R) and the Gs protein, promoting a cAMP/PKA-dependent aquaporin insertion in apical membranes of principal cells of the renal collecting ducts and ultimately, water reabsorption. Molecular mechanisms underlying activation of this critical G protein-coupled recept...

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Literature Corpus work: def457d6-3e32-5d69-8e8a-b8f3a54b3fbf
DOI: 10.1101/2020.12.22.424028

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