Article
Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.
Molecular pharmacology - 1 May 2010
Rochdi Moulay D, Vargas Gabriel A, Carpentier Eric, Oligny-Longpré Geneviève, Chen Stanford, Kovoor Abraham, Gitelman Stephen E, Rosenthal Stephen M, von Zastrow Mark, Bouvier Michel
Abstract excerpt
Substitution of arginine-137 of the vasopressin type 2 receptor (V2R) for histidine (R137H-V2R) leads to nephrogenic diabetes insipidus (NDI), whereas substitution of the same residue to cysteine or leucine (R137C/L-V2R) causes the nephrogenic syndrome of inappropriate antidiuresis (NSIAD). These two diseases have opposite clinical outcomes. Still, the three mutant receptors were shown to share constitutive...
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