Aquaporin 2: from its discovery to molecular structure and medical implications.

doi:10.1016/j.mam.2012.03.004

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Article

Aquaporin 2: from its discovery to molecular structure and medical implications.

Molecular aspects of medicine - 1 Jan 2000

Sasaki Sei

Abstract excerpt

This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2. Regarding the structure and function of AQP2, further structural analysis is necessary to understand the basic properties of individual channel function, for examples, such as possible regulation by gating. The critical importance of AQP2 in the urine concentrating ability...

Topics

Animals
Aquaporin 2
Diabetes Insipidus, Nephrogenic
Gene Expression Regulation
Genetic Association Studies
Humans
Kidney Concentrating Ability
Kidney Tubules, Collecting
Mice
Mutation
Proteolysis
Rats
Vasopressins
Water-Electrolyte Balance

Source

Open in PubMed

Identifiers

PMID: 23078817
DOI: 10.1016/j.mam.2012.03.004

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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