Article
Neuroblastoma and MYCN.
Cold Spring Harbor perspectives in medicine - 1 Oct 2013
Huang Miller, Weiss William A
Abstract excerpt
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in...
Topics
- Antigens, Neoplasm
- Apoptosis
- Cell Cycle
- Cell Proliferation
- Gene Amplification
- Gene Expression
- Genes, myc
- Genetic Markers
- Humans
- Mutation
- N-Myc Proto-Oncogene Protein
- Neoplasm Metastasis