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Article

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

3 Dec 2017

Abstract excerpt

Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with high-risk disease and poor prognosis. Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-amplified neuroblastoma and found a preferential dependency on genes encoding the polycomb repressive...

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PMID: 29202477
DOI: 10.1172/jci90793

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