Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channel

Abstract excerpt

<h4>ABSTRACT</h4> Benzodiazepines represent a major class of drugs prescribed as treatments for anxiety, insomnia and seizures. They act by engaging GABA A receptors in the central nervous system to depress neuronal excitability. Here, the polypharmacology of benzodiazepines was explored by studying their engagement of human TRP channels revealing clonazepam acts as a robust and selective activator of the TRPM8...

Topics

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• Gene Expression Regulation
• Membrane Potentials
• Mice
• Mice, Knockout
• Protein Conformation
• Signal Transduction
• Structure-Activity Relationship
• TRPM Cation Channels

Identifiers and source

Literature Corpus work

debb4591-5531-50d6-9f88-1145f15e4403

DOI

10.64898/2026.01.19.700423