Article

Seizures Triggered by Systemic Administration of 4-Aminopyridine Lead to Acute Brain Glucose Hypometabolism in Rats, as Assessed by PET Molecular Imaging

2024-10-25

Abstract excerpt

4-aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K+ channels used to im-prove walking in multiple sclerosis patients, and it may be useful in the treatment of cerebellar diseases. In animal models, 4-AP is used as a convulsant agent. Intrahippocampal 4-AP induces acute local glucose hypermetabolism and significant brain damage, while i.p. administration causes less neuronal damage. This study...

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Literature Corpus work: deab17b5-a3af-5122-b60b-adbf7a1ec6f5
DOI: 10.20944/preprints202410.2027.v1

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