Article

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

2020-02-10

Abstract excerpt

<h4>ABSTRACT</h4> The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate. Because of their unique specificity and essential role in viral polyprotein processing, these proteases are suitable targets for the development of antiviral drugs. In order to obtain near-equipotent, broad-sp...

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Literature Corpus work: de99f1d5-0a34-5ac6-895f-1efa212443aa
DOI: 10.1101/2020.02.10.936898

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