Article

The <i>N</i> -Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Boceprevir is an HCV NSP3 inhibitor that has been explored as a repurposed drug for COVID-19. It inhibits the SARS-CoV-2 main protease (M Pro ) and contains an α-ketoamide warhead, a P1 β-cyclobutylalanyl moiety, a P2 dimethylcyclopropylproline, a P3 tert -butyl-glycine, and a P4 N -terminal tert -butylcarbamide. By introducing modifications at all four positions, we synthesized 20 boceprevi...

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Literature Corpus work: 3a7e3244-e234-57a8-bd24-03138b0fce60
DOI: 10.1101/2021.12.18.473330

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